Meet The Team

Principal Investigator

Yu YE

Yu Ye

UK DRI Group Leader
Lecturer at Imperial College London
Education:
MRC Laboratory of Molecular Biology, University of Cambridge, Ph.D
Imperial College London, BSc Biochemistry/Biotechnology

Profile:  UK DRI -  Imperial College London -  Researcher Interview

Email: yu.ye1@imperial.ac.uk

Bio: After undergraduate studies at Imperial, I continued with a PhD at St John's College, University of Cambridge. My training in David Komander's lab at MRC Laboratory of Molecular Biology combined structural biology with biophysical techniques to study molecular details underlying regulation in the ubiquitin-proteasome system (UPS). Following this, I was fortunate to secure funding first through a Henslow Junior Research Fellowship and then a Sir Henry Wellcome Research Fellowship to study the UPS and protein aggregation with super-resolution imaging techniques. Working between David Klenerman's group at Cambridge and Daniel Finley's group at Harvard, my research focused on using the UPS system to remove protein aggregates. I am now excited to join UK DRI at Imperial College London, where my group continues to study the interplay between UPS, protein aggregation, neurodegeneration and neuroinflammation.

Current researchers

Michael

Michael Morten

Research Associate in Biophysics
Education:
University of St Andrews, Ph.D Biology
University of Oxford, MChem

Email: m.morten@imperial.ac.uk

Bio: I currently work on developing novel techniques to image aggregates in cells and tissues. I have previously used single-molecule TIRF and confocal microscopes in my PhD research (University of St Andrews) and postdoc projects (University of Glasgow and NYU School of Medicine), and I am now in the process of building a new light sheet microscope here in the Ye Group at the UK DRI at Imperial.

Emma

Emma Mee Hayes

Research Associate in Stem Cell Biology
Education:
Univeristy of Oxford, Ph.D Neuroscience
Trinity College Dublin, MSc Neuroscience
University College Dublin, BSc Biomedical, Health and Life Sciences

Email: e.mee-hayes@imperial.ac.uk

Bio: I completed my PhD studies at the Cader lab in a collaborative project between the University of Oxford and the pharmaceutical company Roche. My research focused on using a CRISPR-screen to study the effects of the mammalian Target of Rapamycin (mTOR) pathway on tau aggregation in iPSC-derived neurons. I joined the Ye lab in March, 2020 where I am researching the function of the proteasome in patient-derived iPSC neurons.

Current students

Liina

Liina Sirvio

Graduate Student
Education:
Imperial College London, MRes Molecular and Cellular Biosciences.
King's College London, BSc Biochemistry

Profile:  Imperial College London

Email: l.sirvio18@imperial.ac.uk

Bio: I am a PhD student at the UK Dementia Research Institute investigating the role of post-translational modifications of amyloid proteins in the pathogenesis of Alzheimer’s and Parkinson’s diseases. Prior to starting my PhD, I completed my BSc in Biochemistry at KCL, MRes at Imperial College London, and worked as a research technician in the Ultanir Lab at The Francis Crick Institute.

Sandra

Sandra Tan

Undegraduate Project Student
Education:
Imperial College London, BSc Medical Biosciences 2022

Email: sandra.tan19@imperial.ac.uk

Bio: I am a undergraduate student studying for a BSc Medical Biosciences at Imperial College London. Currently, I am taking up a six months research project in the Ye lab, developing novel approaches to study aggregate spreading between neuronal and glial cells.

Tom

Tom Chua

Graduate Project Student
Education:
Imperial College London, MRes Drug Discovery and Development 2022
University of Warwick, BSc Chemistry with Medicinal Chemistry

Email: t.chua21@imperial.ac.uk

Bio: I am a graduate student studying for a MRes Drug Discovery and Development at Imperial College London.

Immy

Imogen Hequet

Graduate Project Student
Education:
Imperial College London, MSc Health Data Analytics and Machine Learning 2022
University of Oxford, BA

Email: imogen.hequet21@imperial.ac.uk

Bio: I am a graduate student studying for a MSc Health Data Analytics and Machine Learning at Imperial College London. Prior to starting my Masters, I studied Human Sciences at Oxford.

Katy

Katy Guo

Graduate Project Student
Education:
Imperial College London, MSc Health Data Analytics and Machine Learning 2022
Beijing Normal University, BSc Applied Statistics

Email: yuhan.guo21@imperial.ac.uk

Bio: I am a graduate student studying for a MSc Health Data Analytics and Machine Learning at Imperial College London. Prior to starting my Masters, I have worked as a data scientist and analyst at several major international companies.

Katy

Yiqing Yao

Graduate Project Student
Education:
Imperial College London, MSc Optics and Photonics 2022
Beijing Institute of Technology, BSc Opto-Electronics Information Science and Engineering

Email: yuhan.guo21@imperial.ac.uk

Bio: I am a graduate student studying for a MSc Optics and Photonics at Imperial College London. My research in the lab is to develop an automated azimuthal TIRF system for rapid 3D image acquisition.

Alumni

Katiuska (Dani) Pulgar-PrietoMPhil student
Education: Stony Brook University, BSc Biochemistry
Huzefa RupawalaResearch Associate in Neurobiology
Education: King's College London, Ph.D Neuroscience
Aitor Franco BudiaVisiting PhD student
Education: Biofisika Institute, University of the Basque Country (UPV/EHU), PhD 2021

Undegraduate project students

Matilda BurridgeUROP Student
Education: Imperial College London, BSc Biochemistry 2022
Jasmine KaurUROP Student
Education: Imperial College London, BSc Biochemistry 2022
Elliot ColmanUndergraduate Project Student
Education: Imperial College London, MBBS Pre-Clinical Medicine
Roshni JohnsonUndergraduate Project Student
Education: University of Belfast, MBBS Pre-Clinical Medicine
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Website designed by Huzefa Rupawala.
  yu.ye1@imperial.ac.uk ·  +44 20 7594 5484