Meet The Team

Principal Investigator

Yu YE

Yu Ye

Principal Investigator
Lecturer in Dementia Research
at Imperial College London
Education:
MRC-LMB, University of Cambridge, Ph.D
Imperial College London, BSc Biochemistry/Biotechnology

Profile:  UK DRI -  Imperial College London -  Researcher Interview

Email: yu.ye1@imperial.ac.uk

Bio: I grew up in a Nordic university town and completed a bilingual International Baccalaureate at the local Cathedral School. After undergraduate studies at Imperial, I continued with a PhD at St John's College, University of Cambridge. My training in David Komander's lab at MRC Laboratory of Molecular Biology combined structural biology with biophysical techniques to study molecular details underlying regulation of the ubiquitin-proteasome system (UPS). Following this, I was fortunate to secure funding first through a Henslow Junior Research Fellowship and then a Sir Henry Wellcome Research Fellowship to study the UPS and protein aggregation with super-resolution imaging techniques. Working between David Klenerman's group at Cambridge and Daniel Finley's group at Harvard, my research focused on exploiting the UPS system to remove protein aggregates. During this time, I also served as a Fellow and later also Director of Studies in Natural Sciences at the beautiful Selwyn College, Cambridge, where I still hold many fond memories.
My group at the UK DRI at Imperial College London continues to study the interplay between UPS, protein aggregation, neurodegeneration and neuroinflammation.

Research staff

Georgie

Georgie Lines

Research Associate in Cellular Neuroscience
Education:
University College London, PhD
King's College London, BSc

Email: g.lines@imperial.ac.uk

Bio: I completed my PhD in Neuroscience with Professor Selina Wray, where I studied protein degradation systems in IPSC-neurons of tauopathies. My experience with the proteasome system during this time was fortified with a short interlude in the Hochstrasser lab at Yale. In the Ye lab, I will focus my research on protein aggregates and crosstalks in cellular degradation mechanisms that protect against proteotoxicity.

Mike

Michael Morten

Research Associate in Biophysics
Education:
University of St Andrews, PhD Biology
University of Oxford, MChem

Email: m.morten@imperial.ac.uk

Bio: I currently work on developing novel techniques to image aggregates in cells and tissues. I have previously used single-molecule TIRF and confocal microscopes in my PhD research (University of St Andrews) and postdoc projects (University of Glasgow and NYU School of Medicine), and I am now in the process of building a new light sheet microscope here in the Ye Group at the UK DRI at Imperial.

Hailey

Hailey Gu

Research Technician in Computational Biology
Education:
Imperial College London, MSc Machine Learning
University of California, Berkeley, BA Biology

Email: junting.gu22@imperial.ac.uk

Bio: I was a MSc student studying Healthy Data Analytics at Imperial College London and joined the lab for my research project. My current research continues to focuse on characterising the distinct aggregate species found in different neurodegenerative disorders through quantitative image analysis approaches.

PhD candidates

Liina

Liina Sirvio

PhD Student
Education:
Imperial College London, MRes Molecular and Cellular Biosciences.
King's College London, BSc Biochemistry

Profile:  Imperial College London

Email: l.sirvio18@imperial.ac.uk

Bio: I am a PhD student at the UK Dementia Research Institute investigating the role of post-translational modifications of amyloid proteins in the pathogenesis of Alzheimer’s and Parkinson’s diseases. Prior to starting my PhD, I completed my BSc in Biochemistry at KCL, MRes at Imperial College London, and worked as a research technician in the Ultanir Lab at The Francis Crick Institute.

Mattie

Matilda Burridge

PhD Student
Education:
Imperial College London, BSc Biochemistry with French

Profile:  Imperial College London

Email: matilda.burridge18@imperial.ac.uk

Bio:Matilda, or Mattie, is funded by the prestigous President's PhD Scholarship, awarded whilst she was finishing her BSc degree. Mattie's project in the lab is to study the role of immunoprotasomes in tauopathies. Prior to starting her PhD, Mattie did research in the Ye lab as a UROP student to develop cell lines for protein aggregation assays.

Project students

Lee Ann

Lee Ann Madissoon

Project Student
Education:
Imperial College London, BSc Medical Biosciences 2024

Email: lee.madissoon21@imperial.ac.uk

Bio: I am a project student now in the final year of the BMB course. My research in the lab will characterise pathological aggregates from different dementia types and profile their protein composition and toxicity.

Alumni

Huzefa RupawalaResearch Associate in Neurobiology
Education: King's College London, Ph.D Neuroscience
Emma Mee HayesResearch Associate
Education: Univeristy of Oxford, Ph.D candidate;
Sandra TanUndegraduate Project Student
Education: Imperial College London, BSc Medical Biosciences
Katiuska (Dani) Pulgar-PrietoMPhil student
Education: Stony Brook University, BSc Biochemistry
Ziba ShadmanIndustry-contracted technician
Education: Imperial College London;
Aitor Franco BudiaVisiting PhD student
Education: Biofisika Institute, University of the Basque Country (UPV/EHU), PhD

Former project students

Yujiao FanUROP Student
Education: Imperial College London, BSc Medical Biosciences 2024
Hailey GuMSc Student
Education: Imperial College London, Health Data Analytics and Machine Learning 2023
Annika KeshuUROP Student
Education: Imperial College London, MEng Bioengineering, 2023
Suqian ZhangMRes Student
Education: Imperial College London, MRes Experimental Neuroscience, 2023
Swathi GiridharMSc Student
Education: Imperial College London, MRes Biomedical sciences, Data Science stream, 2023
Katy GuoMSc Student
Education: Imperial College London, Health Data Analytics and Machine Learning 2023
Anson WongBSc Student
Education: Imperial College London, BSc Medical Biosciences 2023
Cameron BeaneyBSc Student
Education: Imperial College London, BSc Medical Biosciences 2023
Imogen HequetMSc Student
Education: Imperial College London, MSc Health Data Analytics and Machine Learning 2022
Katy GuoMSc Student
Education: Imperial College London, MSc Health Data Analytics and Machine Learning 2022
Thomas ChuaMRes Student
Education: Imperial College London, MRes Drug Discovery and Development 2022
Yujean KimUROP Student
Education: Imperial College London, BSc Biological Sciences 2022
Yiqing YaoMSc Student
Education: Imperial College London, MSc Optics and Photonics 2022
Matilda BurridgeUROP Student
Education: Imperial College London, BSc Biochemistry 2022
Jasmine KaurUROP Student
Education: Imperial College London, BSc Biochemistry 2022
Elliot ColmanUndergraduate Project Student
Education: Imperial College London, MBBS Pre-Clinical Medicine
Roshni JohnsonUndergraduate Project Student
Education: University of Belfast, MBBS Pre-Clinical Medicine
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