Meet The Team

Bio: I currently work on developing novel techniques to image aggregates in cells and tissues. I have previously used single-molecule TIRF and confocal microscopes in my PhD research (University of St Andrews) and postdoc projects (University of Glasgow and NYU School of Medicine), and I am now in the process of building a new light sheet microscope here in the Ye Group at the UK DRI at Imperial.

Bio: I was a PhD student in Tony Schapira’s lab studying the molecular and cellular interactions between LRRK2 and GBA1 in Parkinson’s disease using iPSC and mouse models. I have now returned to Imperial to start a collaborative project with Eisai, focusing on targeting proteostasis systems in synucleinopathy models with an emphasis on multidisciplinary translational research.

Bio: I was a PhD student in Angela Hodges’s lab funded by the MRC-DTP to study Alzheimer’s risk gene TREM2 in microglia. During this time, I generated CRISPR-edited iPSC KO cell lines in which I developed and optimised assays investigating phagocytosis, lipid droplets and cellular metabolism. In the Ye lab, I will study how proteasomes clear tau aggregates in model neurons.

Bio: I did my undergraduate at Edinbrugh and just completed a MSc in Immunology here at Imperial. I am currently supporting various projects using IPSC-neurons as tauopathy and synucleinopathy models to study the build-up and clearance of protein aggregates.

Bio:Matilda, or Mattie, is funded by the prestigous President's PhD Scholarship, awarded whilst she was finishing her BSc degree. Mattie's project in the lab is to study the role of immunoprotasomes in tauopathies. Prior to starting her PhD, Mattie did research in the Ye lab as a UROP student to develop cell lines for protein aggregation assays.

Bio:I am completing the first year of my PhD journey in the Ye lab, working on a collaborative project to validate a potential drug target in Parkinson's disease cell models. This project is funded by Parkinson's UK. Before my PhD, I earned my master's in Translational Neuroscience at Imperial College London and worked as a research technician in the UK Dementia Research Institute for a year.

Bio:I am a graduate of the University of Hong Kong’s BSc in Molecular Biology & Biotechnology and now an MRes student at Imperial College London. I am excited to join the Ye Lab for my research project, where I will be investigating the specificity of drugs for distinct proteasome active sites and their potential therapeutic applications in cancer.

Bio:I am a graduate of the Xi’an Jiaotong Liverpool University in Biological Science and now an MRes student now an MRes student in Biomedical Research (Molecular Basis of Human Disease Stream) at Imperial College London. My research project in Ye lab aimed to develop a standardized in vitro disease-relevant tau aggregation model for studying how tau pathology causes neuronal stress and spreads between cells.

Bio:Hi, I am a Molecular Medicine student at the University of Freiburg in Germany with a keen interest in ageing and dementia. I am excited to join the Ye lab and gain my first research experience in this field.

Bio:Nicole is currently completing an MSc in Genomic Medicine at Imperial College London. She previously studied Life Sciences at Yale-NUS College and conducted research on neurodevelopmental disorders at Yale School of Medicine and A*STAR/NUS. In the Ye lab, she is interested in studying cellular mechanisms underlying neurodegeneration and protein aggregation in neurological disease.

Bio:I completed my BSc in Neuroscience (Hons) at University College London, and now pursuing an MRes in Experimental Neuroscience at Imperial College London. My research interests include translational and pharmacological approaches to neurodegenerative disorders, particularly prion-like propagation mechanisms, as well as neuro-oncology. In my current project with the Ye Lab, my work examines the proteostasis of synucleinopathy aggregates in Parkinson’s disease.

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