Publications

2022

phosphotau

15. Meng J.X., Zhang Y., Saman D., Haider A.M., De S., Sang J.C., Brown K., Jiang K., Humphrey J., Julian L., Hidari E., Lee S.F., Balmus G., Floto R.A., Bryant C., Benesch J., YE Y., Klenerman D.   Hyperphosphorylated tau self-assembles into amorphous aggregates eliciting TLR4-dependent responses  (2022) Nature Communications
doi: https://doi.org/10.3389/fnagi.2022.854380

TAAD review

14. Mee Hayes E., Sirvio L., YE Y.   A Potential Mechanism for Targeting Aggregates With Proteasomes and Disaggregases in Liquid Droplets  (2022) Frontiers in Aging Neuroscience
Review
doi: https://doi.org/10.3389/fnagi.2022.854380

2021

Paper

13. Li, B., Ponjavic, A., Chen, W. H., Hopkins, L., Hughes, C., YE Y. Bryant, C. and Klenerman, D.   Single-Molecule Light-Sheet Microscopy with Local Nanopipette Delivery  (2021) Analytical Chemistry
doi: https://doi.org/10.1021/acs.analchem.0c05296

2020

12. Zuo, Y., Chong, B. K., Jiang, K., Finley, D. J., Klenerman, D. and YE Y.,   A general in vitro assay to study enzymatic activities of the ubiquitin system  (2020) Biochemistry
doi: https://doi.org/10.1021/acs.biochem.9b00602

11. YE Y., Klenerman, D. and Finley, D.   N-Terminal Ubiquitination of Amyloidogenic Proteins Triggers Removal of Their Oligomers by the Proteasome Holoenzyme  (2020) Journal of Molecular Biology
doi: https://doi.org/10.1016/j.jmb.2019.08.021

2019

10. Cliffe, R., Sang, J. C., Kundel, F., Finley, D., Klenerman, D. and YE Y.,   Filamentous Aggregates Are Fragmented by the Proteasome Holoenzyme  (2019) Cell Reports
doi: https://doi.org/10.1016/j.celrep.2019.01.096

2018

9. Ponjavic, A., YE Y., Laue, E., Lee, S. F. and Klenerman, D.   Sensitive light-sheet microscopy in multiwell plates using an AFM cantilever  (2018) Biomedical Optics Express
doi: https://doi.org/10.1364/BOE.9.005863

8. Zhang, Y., Lippert, A. H., Lee, J. E., Carr, A. R., Ponjavic, A., Lee, S. F., Finley, D., and Klenerman, D. and YE Y.   Membrane potential regulates the dynamic localisation of mammalian proteasomes  (2018) bioRxiv
doi: https://doi.org/10.1101/487702

2016

7. Iljina, M., Tosatto, L., Choi, M. L., Sang, J. C., YE Y., Hughes, C. D., Bryant, C. E., Gandhi, S. and Klenerman, D. 2016   Arachidonic acid mediates the formation of abundant alpha-helical multimers of alpha-synuclein  (2016) Scientific Reports
doi: https://doi.org/10.1038/srep33928

2012

6. YE Y., Blaser, G., Horrocks, M. H., Ruedas-Rama, M. J., Ibrahim, S., Zhukov, A. A., Orte, A., Klenerman, D., Jackson, S. E. and Komander, D.  Ubiquitin chain conformation regulates recognition and activity of interacting proteins  (2012) Nature
doi: https://doi.org/10.1038/nature11722

5. Agromayor, M., Soler, N., Caballe, A., Kueck, T., Freund, S. M., Allen, M. D., Bycroft, M., Perisic, O., YE Y., McDonald, B., Scheel, H., Hofmann, K., Neil, S. J. D., Martin-Serrano, J. and Williams, R. L.   The UBAP1 Subunit of ESCRT-I Interacts with Ubiquitin via a SOUBA Domain  (2012) STRUCTURE
doi: https://doi.org/10.1016/j.str.2011.12.013

2011

4. YE Y., Akutsu, M., Reyes-Turcu, F., Enchev, R. I., Wilkinson, K. D. and Komander, D.  Polyubiquitin binding and cross-reactivity in the USP domain deubiquitinase USP21 (2011) EMBO Reports
doi: https://doi.org/10.1038/embor.2011.17

3. Akutsu, M., YE Y., Virdee, S., Chin, J. W. and Komander, D.  Molecular basis for ubiquitin and ISG15 cross-reactivity in viral ovarian tumor domains (2011) Proceedings of the National Academy of Sciences of the United States of America
doi: https://doi.org/10.1073/pnas.1015287108

2010

2. Virdee, S., YE Y., Nguyen, D. P., Komander, D. and Chin, J. W.  Engineered diubiquitin synthesis reveals Lys29-isopeptide specificity of an OTU deubiquitinase (2010) Nature Chemical Biology
doi: https://doi.org/10.1038/nchembio.426

2009

1. YE Y., Scheel, H., Hofmann, K. and Komander, D.  Dissection of USP catalytic domains reveals five common insertion points (2009) Molecular BioSystems
doi: https://doi.org/10.1039/b907669g

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